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1.
Molecular Glues: Capable Protein-Binding Small Molecules That Can Change Protein-Protein Interactions and Interactomes for the Potential Treatment of Human Cancer and Neurodegenerative Diseases.
Int J Mol Sci
; 23(11)2022 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35682885
2.
FL118, acting as a 'molecular glue degrader', binds to dephosphorylates and degrades the oncoprotein DDX5 (p68) to control c-Myc, survivin and mutant Kras against colorectal and pancreatic cancer with high efficacy.
Clin Transl Med
; 12(5): e881, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35604033
3.
Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell carcinoma.
J Exp Clin Cancer Res
; 40(1): 254, 2021 Aug 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34384473
4.
Mutant Kras as a Biomarker Plays a Favorable Role in FL118-Induced Apoptosis, Reactive Oxygen Species (ROS) Production and Modulation of Survivin, Mcl-1 and XIAP in Human Bladder Cancer.
Cancers (Basel)
; 12(11)2020 Nov 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-33217967
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